ABSTRACT

Background: It has been well referred that lignan family of natural products has goodpharmacological potential. A lignan, Niranthin, 6-[(2R,3R)-3-[(3,4-dimethoxyphenyl)methyl]-4- methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole] is a common phytoconstituents from various Phyllanthus species. Objectives: This study aims to investigate chronic pain modulatory potential of Niranthin. Materials and Methods: We have investigated the effects of Niranthin on chronic thermal and mechanical hypersensitivities in rats, which were injected with 3% carrageenan in the left gastrocnemius muscle and hyperalgesia to heat and mechanical stimuli was assessed before and at varying times after injection, till end of 22 days after muscle insult. Histological changes and the determination of prostaglandin E2 (PGE2) concentration were performed after the completion of drug treatment protocol. Results: Our finding noted that Niranthin causes hypersensitivityactivity, when administered intraperitoneally. There was also reduction in prostaglandin E2 (PGE2) concentration observed during our analysis. Conclusion: To summarize, we wish to report chronic inflammatory pain modulating potential of Niranthin in current pain model and are thought to be mediated via spinal or supraspinal neuronal mechanisms, mainly inhibiting PGE2. Since, our current study is preliminary in nature, further in detailed molecular investigation will be needed to predict drug-like candidature of Niranthin as pain modulating agent. Keywords: Niranthin; lignan; Anti-hyperalgesic activity; chronic muscle pain; pain modulating potential
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6413.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.9.6413