ABSTRACT

Floating drug delivery systems improves the drug bioavailability and patient compliance by increasing the gastric residence time and controlling the drug release. In recent decades, there have been numerous attempts to overcome the barriers like short gastric residence times and unpredictable gastric emptying times. In this review, the technological and research advancements made in floating systems are discussed. Oral drug delivery system is the most preferred route of administration for drug delivery. In the development of the drug delivery system many components play important role. Polymers are amongst those components which have evolved with the drug delivery system. Polymers are the macromolecule compound containing many monomer units joined to each other by bonds. The floating drug delivery systems (FDDS) become an additional advantage for drugs that are absorbed primarily in the upper segments of gastrointestinal (GI) tract, i.e., the stomach, duodenum and jejunum. The purpose of writing this review on floating drug delivery systems (FDDS) was to focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention and polymers used in floating Drug delivery systems. Polymers used in the drug delivery system are of two types Natural and Synthetic based on their origin. Both types of the polymers have some advantages and disadvantages. This particular article gives information about the different types of natural and synthetic polymer used in the drug delivery system. Natural polymers like guar gum, chitosan, xanthan gum, Gellan gum and sodium alginate are mentioned in the article. Synthetic polymers mentioned are HPMC, Eudragit, and Ethyl cellulose. Keywords: Floating drug delivery system, Dosages form, Technology for preparation
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6403.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.9.6403