ABSTRACT

In terms of the administration of drugs, oral administration is the most prevalent and favoured mode of administration because of its simplicity and ease of consumption. The water solubility, drug permeability, dissolution rate, and first-pass metabolism of a medication all affect oral bioavailability. Novel chemical entities are created in pharmaceutical companies to account for more than 40% of poorly water-soluble drugs. Drugs with low water solubility may be improved by using the solid dispersion approach. Solvent-free solid dispersion may be made using this method. One or more of the methods listed in this study may be employed to improve the drug's solubility. The most critical consideration when choosing a solubilityenhancing approach is ensuring that the intended objectives are achieved. Dispersion of a solid method involves a variety of mechanisms. The dissolving of solids is carried out using a variety of methods and characterizations. Hence, this review will be used for new formulation of drugs to provide good solubility if the drugs have been low solubility in the upcoming drug developments. Keywords: New drugs, poorly water solubility, solid dispersion, enhancement techniques
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6398.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.9.6398