ABSTRACT

Introduction: Gandhaka is an excellent rejuvenator that falls within the uparasa classification.. Drosophila is an ideal model organism for exploring ageing and lifespan mechanisms. Aim: To study the effect of Shuddha Gandhaka in extending the life span of Drosophila melanogaster adopting adult feeding method. Materials and Methods: Regular feeding media was combined with Shuddha Gandhaka at varying concentrations (12.5 mg/100 ml, 25 mg/100 ml, and 37.5 mg/100 ml) for the experimental setup. All the groups were given the same medium until it died. Results: In the experimental media treated with Shuddha Gandhaka, there was an increase in lifespan. The effect of Shuddha Gandhaka on the longevity of Drosophila melanogaster were shown to be notable. The results clearly show that the G IV group had a 36.79 percent increase in life span, with a mean life span of 62.37. It was discovered that there was a significant difference between the control and treatment groups. The findings appear to extend the lifespan of Drosophila melanogaster and to be consistent with their indicated human doses in Ayurvedic treatment. Conclusion: In the context of the reported "Longevity" effects of Shuddha Gandhaka, the present in vivo study on a model organisms shows that Shuddha Gandhaka feeding significantly improves the life span of Drosophila melanogaster. Keywords: Drosophila melanogaster, Shuddha Gandhaka, Longevity, Rasayana
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6372.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.9.6372