ABSTRACT

Objective: Aim of this study was to develop and evaluate the Ufasomal suspension of Voriconazole. Voriconazole is a broad spectrum, triazole antifungal agent. Mostly Voriconazole is used topically for Cutaneous Fusarium Solani infection. But for topical administration there are no available dosage form. So, for better topical administration, Voriconazole is loaded into Ufasomes in which drug will be in nano size vesicles. Methods: The present study aims to load Voriconazole into ufasomes by using thin film hydration method. Voriconazole loaded ufasomes were prepared using cholesterol and sodium oleate in different ratios. Prepared vesicles were characterized for size, polydispersity index , entrapment efficiency ,thermal behavior (Differential scanning calorimetry) ,invitro release studies and invitro skin permeation studies. Results: Phospholipid and surfactant ratios played a remarkable role to determine the zeta potential and vesicle size of the vesicles. The vesicle size was found to be 201.30nm and the zeta potential was found to be -38.6mV. The entrapment efficiency of vesicles is in the range of 76.48% to 85.38%. The invitro drug release studies of all the five formulations shows drug release more than 62% by the end of 24hrs. Conclusion: On the basis of findings, the study revealed that entrapment of hydrophobic drugs into lipid based vesicles can improve topical bioavailability. However, the results from this study fulfilled that the Voriconazole is loaded into ufasomes for better topical administration. Keywords: Ufasomes, Voriconazole , fungal infection, sodium oleate , cholesterol, triazole
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6360.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.9.6360