ABSTRACT

Solubility is an important parameter for dosage form. According to BCS Classification Class II drug has low water solubility effects its dissolution and bioavailability of drug. The various methods are used to improve solubility of drug by chemical modification and physical modification such as solid dispersion, co solvent method and cyclodextrin encapsulation. This study is important to understand the difference between various methods used to enhance solubility. It is useful to reduce toxicity by reducing dose of drug. To improve absorption and dissolution of drug to achieve better therapeutic response. The solubility of a drug molecule plays a vital role in its bioavailability, as the aqueous solubility of poorly water soluble drugs (BCS class II) molecule in gastrointestinal fluid often causes unsatisfactory bioavailability, poorly aqueous soluble drugs often requires high dose in order to reach therapeutic plasma concentration. After oral administration of any BCS class II drug to be absorbed must be present in the form of aqueous solution at the site of absorption. Keywords: Sertaconazole, Cyclodextrin, Solubility, absorption, bioavailability , toxicity
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6220.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.9.6220