ABSTRACT

The objectives of present investigation were to prepare & evaluate Eudragit S-100 based nanoparticles of diltiazem HCl by solvent evaporation technique. The naonoparticles were prepared by solvent evaporation technique by using eudragit S100 as a polymer with different concentrations, methanol and ethyl acetate as a solvent and antisolvent respectively. Nanoparticles were characterized for Drug content, FTIR, Zeta potential, Particle size distribution, DSC, SEM and In-vitro release study and Stability study. All the batches showed drug content in the range 94.50% to 99.07%. Particle size was found in the range of 189.8- 144.5 nm. Zeta potential values of formulations were from -2.58 mV to -24.70mV & formulation comply with requirement of Zeta potential for stability. Nanoparticles exhibited increased dissolution rate, compared to raw material due to reduction in particle size, increased surface area & solubility in lower gastrointestinal conditions. The prepared nanoparticles by solvent evaporation method of diltiazem HCl and different concentrations of Eudragit S-100 will prevent premature drug release in upper gastrointestinal tract will be useful for prevention of cardiovascular diseases as chronotherapeutic drug delivery. Keywords: Nanoparticles, Chronotherapeutic, diltiazem hydrochloride, Solvent Evaporation, Eudragit S-100
Publication date: 01/09/2022

https://ijbpas.com/pdf/2022/September/MS_IJBPAS_2022_6036.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.9.6036