ABSTRACT

Saccharomyces boulardii, is the unique yeast probiotic that has been effectively used as a good biotherapeutic agent. In aerobic respiration it produces CO2 and H2O and in anaerobic alcoholic fermentation it generates ethanol and CO2. In present investigation this property of yeast is used to generate carbon dioxide in floating tablet. Furosemide is selected as model drug for the development of a floating drug delivery system. Floating tablet prepared by direct compression using Saccharomyces boulardii probiotics formulations as floating agent due to its ability to generate carbon dioxide gas and its safety. Different grades of Hydroxy propyl methyl cellulose (HPMC), Carboxy methyl cellulose sodium (CMC sodium) are used as hydrophilic polymers . Calcium hydroxide is used as PH modifier which enhance solubility of furosemide and also maintain integrity of matrix. we concluded that HPMC has capacity to form a more stable gel than CMC sodium . In vitro buoyancy study and dissolution study showed that floating tablet containing HPMC E 15 LV floated for more than 24 hr and 85.36 ± 0.53 % drug release up to 12hr. Saccharomyces boulardii formulation was good floating agent and it’s very easy to prepare tablet using this novel floating agent in combination with different hydrophilic polymers. Keywords: Saccharomyces boularddii, probiotics, facultative anaerobe, hydrophilic polymers, furosemide
Publication date: 01/08/2022

https://ijbpas.com/pdf/2022/August/MS_IJBPAS_2022_6316.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.8.6316