ABSTRACT

Deltamethrin (DLM) is a type-II synthetic pyrethroid insecticide which is used extensively to get rid of pests in agricultural practices as well as to combat against insect-vector borne disease. Exposure of deltamethrin (DLM) to humans and other animals leads to toxicity of various vital tissues, the present study is an extension to provide primary understanding of sub-chronic toxicity of pyrethroids in digestive tissues by evaluating the oxidative stress induced by the DLM. Moreover, the protective effects of Zingiber officinale (ZO) against Gastro-intestinal toxicity in female mice was evaluated. Female Swiss albino mice were divided into seven experimental groups: Group I served as the control group. Group II served as vehicle control (peanut oil) and Group III administered with 100 mg/kg b.wt. ZO only. Group IV and Group V animals were given 3 mg/kg b.wt and 6 mg/kg b.wt of DLM respectively while Group VI and Group VII mice were given 3 mg/kg b.wt. of DLM+100 mg/kg b.wt ZO and 6 mg/kg b.wt of DLM+100 mg/kg b.wt ZO respectively for a period of 45 days to female mice. Results showed that DLM administration increased lipid peroxidation of stomach and intestine and have negative impact Glutathione (GSH) and the activities of antioxidative enzymes including Superoxide Dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx) and Glutathione reductase (GRx). Further, co-administration of ZO along with DLM brought the recovery to the normal antioxidant status. Hence, it can be concluded that ZO has potential benefits and could be able to mitigate DLM induced oxidative stress. Keywords: Deltamethrin, Pyrethroids, Oxidative stress, Gastro-intestinal toxicity, Zingiber officinale, Antioxidants
Publication date: 01/08/2022

https://ijbpas.com/pdf/2022/August/MS_IJBPAS_2022_6299.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.8.6299