ABSTRACT

Introduction: Patoladi tablet (PT) is a polyherbal formulation widely used in Ayurvedic clinical practice with multi fold benefits, specifically to combat chronic tonsillitis in children. There is no work on record on formulation and standardization aspect of compound formulation Patoladi tablet. This paper highlights the preparation, physico-chemical characterization, TLC and HPTLC densitogram profiling of Patoladi tablet which can be applied for authentication of this herbal formulation. Methods: Eleven herbal drugs namely Patola (Tricosanthus dioica), Shunti (Zingiber officinale), Harithaki (Terminalia chebula), Vibhithaki (Terminalia belerica), Amalaki(Emblica officinalis), Vishala (Cytrullus colocynthis), Brahmi (Bacopa monnieri), Katuki (Picrorrhiza kurroa), Haridra (Curcuma longa), Daruharidra (Berberis aristate), Guduchi (Tinospora cordifolia) were authenticated botanically. The tablets were prepared by combining all these drugs and subjected for detailed physico-chemical and HPTLC analyses. Results: Set of standardization parameters were derived for the compounded tablet containing eleven herbs by physico-chemical characterisation. The tests proposed would serve as diagnostic parameters for the identity of this polyherbal formulation. HPTLC fingerprint profile which can serve as a fingerprint for the identification of the formulation has been obtained. Conclusion: The proposed method of making tablet from eleven herbs will aid in yielding concentrated medicament with the same efficacy as per the classically proposed drug dosage at lower dose. Standards for the herbal formulation has been developed for the quality check of the formulation. Keywords: Patoladi tablet, chronic tonsillitis, physico-chemical characterization, TLC and HPTLC densitogram
Publication date: 01/08/2022

https://ijbpas.com/pdf/2022/August/MS_IJBPAS_2022_6291.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.8.6291