ABSTRACT

Back ground: It is a challenge to provide the constant drug concentration in blood there by increasing the patient compliance it can be overcome by the microspheres. Objective: The primary objective of the research work was to prepare, characterize and evaluate controlled release microspheres of risperidone. Method: The method used for preparation of risperidone microspheres is by using nonaqueous solvent evaporation technique to facilitate the delivery of the drug at a predetermined rate for a specific period of time. Results: All the formulated microparticles were subjected to various evaluation parameters such as particle size analysis, micrometric properties, drug entrapment efficiency, percentage drug loading, percentage yield and in vitro drug release study. The compatibility of the drug and polymers was confirmed by physical compatibility study, fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC). The formation of the most optimized batch of the microsphere (F9) was confirmed by scanning electron microscopy (SEM), DSC, FTIR. Conclusion: As a result, the current work demonstrates the successful formulation of controlled release microspheres of risperidone using the solvent evaporation method and appropriate polymers such as hydroxy propyl methyl cellulose and ethyl cellulose. This study has been a satisfactory attempt to formulate a micro-particulate system of risperidone with a view of controlled delivery of the drug. Keywords: Risperidone, Microspheres, Hydroxy propyl methyl cellulose, Ethyl cellulose
Publication date: 01/08/2022

https://ijbpas.com/pdf/2022/August/MS_IJBPAS_2022_6290.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.8.6290