ABSTRACT

This research aims to formulate and quantify nanoemulsion which contains L-glutathione reduced with antioxidant and antimelanogenic activity. The drug was obtained from RP chemical Pvt. Ltd. Mumbai India identified with certificate of analysis. Total 9 batches preformulation were prepared by taking the proportion of the excipients and variables as factors. The nanoemulsions were prepared using the Phase Inversion Emulsion (EPI) technique. Nanoemulsion formulations were prepared simultaneously by heating both phases, dissolving the reduced L-glutathione in aqueous form. It used orange oil as an oily stage, and PEG-400. Parameters such as organoleptic properties, appearance tests, dye solubilization, pH, viscosity, dispensability tests, refractive index, product consistency, particle size analysis, zeta potential, thermodynamic stability tests, stability tests were performed for all batches. This work offers a stronger release profile of nanoemulsion. Droplet size in nanoformulation is a crucial parameter. Formulation would be suitable for having the smallest particle size. The smaller the larger particle size will be drug absorption in systemic circulation at the lowest possible dosage and optimum therapeutic activity. Reducing dosages of prescribed drugs will further decrease toxicity and side effects. Keywords: Formulation, Antioxidant, Antimelanogenic and L-glutathione
Publication date: 01/08/2022

https://ijbpas.com/pdf/2022/August/MS_IJBPAS_2022_6277.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.8.6277