ABSTRACT

The aim of the present work was to formulate and evaluate in-situ gelling system of Natamycin. Natamycin is an antifungal agent which exhibits rapid precorneal elimination and poor ocular bioavailability, when given in the form of conventional ophthalmic suspensions. To overcome this, an attempt has been made to formulate pH-triggered in situ gelling system of Natamycin to provide sustained release of drug based on polymeric carriers that undergo sol-to-gel transition upon change in pH. The Natamycin in- situ gelling system formulated by using poly acrylic acid (Carbopol 940) in combination with HPMC which acted as viscosity enhancing agent. The formulations were evaluated for clarity, pH measurement, gelling capacity, drug content estimation, rheological study, In vitro diffusion study and antifungal activity. The developed formulation was stable and provided sustained release up to a time period of 8 hrs and it is a viable alternative to conventional eye drops. Keywords: Natamycin; In-situ gel; Carbopol 940
Publication date: 01/08/2022

https://ijbpas.com/pdf/2022/August/MS_IJBPAS_2022_6275.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.8.6275