ABSTRACT

A Series of new 2,5-disubstituted-1,3,4-oxadiazole derivatives are synthesized from hydrazone derivatives along with various aldehydes and ketones derivatives in presence of bromine water, sodium acetate and glacial acetic acid. All the newly synthesized aldehyde and ketone derived 1,3,4-oxadiazoles are characterized using elemental analysis. IR, 1H NMR, 13CNMR spectral characterization was carried out. All the synthesized compounds of 1,3,4-oxadiazole derivatives are evaluated for their anti-microbial activity against several gram-positive bacterial strains (Bacillus subtilis, Bacillus cereus, S.pyrogenous, S.aureus) and gram-negative bacterial strains (E. coli, P. aeruginosa) using broth dilution technique with the discdiffusion method. From the tested compounds OD-2, OD-7, OD-9 showed better activity compared to others. All the derivatives are synthesized by green synthesis techniques. Keywords: 1,3,4-oxadiazole, Broth dilution technique, Disc Diffusion method, Anti-microbial, Green Synthesis
Publication date: 01/08/2022

https://ijbpas.com/pdf/2022/August/MS_IJBPAS_2022_6272.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.8.6272