ABSTRACT

Sublingual route is the most popular route for systemic effects for its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. For drug absorption in oral cavity, sublingual area is most permeable to drugs. The drug delivered by the sublingual route bypasses the hepatic first-pass metabolism and providing acceptable bioavailability. Dysphagia (difficulty in swallowing) is common problem for all age or on reduce liquid intake have difficulties in swallowing the solid dosage forms. This review highlights the mechanism of sublingual absorption, factors affecting sublingual absorption, advantages, disadvantages and evaluation parameters. Keywords: Sublingual route, dysphagia, bioavailability, patient compliance
Publication date: 01/08/2022

https://ijbpas.com/pdf/2022/August/MS_IJBPAS_2022_6271.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.8.6271