ABSTRACT

In recent years the prominence of mini-tablets dosage forms continuously increasing. Minitablets are tiny solid oral dosage forms having diameters ? 3mm. They are like subunits of conventional tablets with same manufacturing process but only alteration is application of multitips tooling. These are patient friendly drug delivery system for patients having swallowing difficulties along with lesser inter-intra individual variability and reduced dose dumping risk. Simplicity and reproducibility of direct compression technique gives uniformity in dosage units compare to conventional granules and pellets manufacturing. The objective of this study is to evaluate feasibility by simple and easy direct compression process as well as process optimization of esomeprazole mini-tablets manufacturing with respect to different levels of drug loading, selection of excipients based on their particle size, particle size distribution and flow characteristics along with modification in conventional excipient addition steps. Keywords: Multi-tips tooling, Dose flexibility, Drug loading optimization, Excipient selection, Particle size distribution, Reproducibility
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6250.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6250