ABSTRACT

Now a day’s innovative dosage forms like mini-tablets which having diameter ? 3mm attaining more eminence due to their simplicity of manufacturing and effective way of drug release mechanisms. They are more effective and patient friendly dosage forms than conventional dosage forms like tablets/capsules due to smaller size. They are manufactured just by modification in compression step using application of multi-tips tooling. Even they are more economical compare to complex and delicate pellets manufacturing process. Primary study shows that esomeprazole accomplishes better and more sustained acid control than other proton pump inhibitors but major problems accompanying are rapid degradation in gastric acid, BCS class III drug, short biological half-life and wide inter-intra individual variability in the bioavailability (50-90%) due to its low permeability. Enteric coated mini-tablets dosage form serves as promising approach as they can protect the drug substance from degradation in gastric media and avoids premature drug release due to smaller size, rapid transit time, higher surface area and higher dispersability in gastro-intestinal tract which leads to improved drug absorption compare to conventional dosage forms. Esomeprazole mini-tablets are manufactured using direct compression technique and further evaluated for optimization of barrier coat and enteric coat using different types and levels of polymers to prepare robust and effective delayed release minitablets of esomeprazole. Keywords: Direct compression, Multi-tips tooling, Barrier coat optimization, Enteric coating polymers
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6249.pdf

Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.7.6249