ABSTRACT

The present investigation was aimed at evaluating the antioxidative and stress resistance efficacy of Bryophyllum pinnatum (BP) extracts using Caenorhabditis elegans as the experimental model. The antioxidant activity of the BP extract was evaluated in vitro (DPPH) and in vivo (DCF-DA assay). Different crude extracts of BP i.e., methanolic, hydromethanolic and aqueous were used to determine impact on lifespan and ROS scavenging activity (20 mM H2O2). The present study revealed that BP crude extracts possess significant in vitro and in vivo antioxidant activities which possibly contributed to its role in enhanced stress tolerance. The crude extracts also proved effective in increasing the mean lifespan of C. elegans following exposure to oxidative stress. The study strongly suggests that the B. pinnatum extract acts as an antistressor and potent scavenger of reactive oxygen species, and consequently enhances the survival of the worms in different stress conditions. Keywords: Antioxidative, Bryophyllum pinnatum, Crude extracts, Caenorhabditis elegans, Antistressor
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6234.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6234