ABSTRACT

Chalcones are the most important precursors for the synthesis of numerous flavonoids and isoflavonoids. These are condensation products of aromatic aldehyde and acetophenone in the presence of a catalyst. The reactions monitored by TLC using Silica gel-G as the adsorbent. The compounds were purified by column chromatography. All the titled (3a-o) compounds were characterized by elemental analysis, IR and 1HNMR spectral data and microanalysis. All the synthesized compounds were screened for biological activities such as antifungal, antitubercular and anticancer activity by using suitable reference standards. All the compounds subjected for biological screening. The compounds 3h and 3o possessed good antifungal activity, 3f and 3h shown excellent antitubercular activity, and the compound 3o shown good cytotoxic activity. The synthesized compounds evaluated for antifungal, antitubercular and anticancer activity. The compounds 3f, 3o, 3h good activity as antifungal, antitubercular, and anticancer agents. These studies may be useful for further developments in future. Keywords: Flavonoids, Condensation, Antifungal, antitubercular, anticancer activity and cytotoxic activity
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6231.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6231