ABSTRACT

The aim of the present investigation is to, formulate and develop a novel oral monolithic, controlled release tablet dosage form for Propranolol hydrochloride to provide steady state drug release over an extended period of time. The drug candidate selected Propranolol hydrochloride was formulated as controlled release matrix tablets which consisted of locast bean gum as polymer, electrolytes and other diluents by wet granulation technique. Electrolytes such as sodium carbonate, magnesium carbonate and calcium carbonate were added at various concentrations in various formulations, while the drug to polymer concentrations was maintained at different ratios respectively. The tablets were analyzed to determine their hardness, friability, dug content and in vitro release profile. The influence of the proportion of the gum and electrolytes on the release rate of the drug from the tablets was evaluated. The drug release rate was influenced by diffusion and swelling mechanisms exhibiting non-Fickian transport. The findings indicated that the swelling and gel formation in the presence of electrolytes within the hydrophilic matrices provided controlled drug delivery of drug from a simple monolithic system. The DSC and FTIR studies indicated that there was no chemical interaction between drug and excipients. Stability studies (40±2ºC/75±5%RH) for 3 months indicated that Propranolol hydrochloride was stable in the matrix tablets. Keywords: Propranolol HCl, Locust Bean Gum, Electrolytes and Controlled release
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6228.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6228