ABSTRACT

Objective: Neuracanthus sphaerostachyus has been traditionally used to treat skin diseases, cough, and asthma. Lack of sufficient scientific evidence indicating the utility of this plant prompted us to investigate the antihistaminic and anticholinergic activities of the plant in different experimental screening methods. Methods: Evaluation of anti-histaminic and anti-cholinergic activity of methanolic & aqueous extract of Neuracanthus sphaerostachyus leaves using histamine and acetylcholine induced contractions on rat isolated tracheal chain and ileum chain preparations. Dose dependent responses to histamine and acetylcholine in absence and presence of aqueous & methanolic extract of Neuracanthus sphaerostachyus were reported. Results: Neuracanthus sphaerostachyus showed inhibition of tracheal chain and ileum contractions in presence of histamine and acetylcholine in dose dependent manner. Higher doses of methanolic extracts have more spasmolytic effect as compare to aqueous extract. Conclusion: It is concluded that methanolic and aqueous extracts of leaves exhibited significant antihistaminic and anticholinergic activity. Keywords: Anticholinergic, Antihistaminic, Inflammation, Asthma, Neuracanthus sphaerostachyus
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6222.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6222