ABSTRACT

The exploration work depends on the turn of events and approval for assessment of ?-? arteether. UV spectroscopy's simple, accurate, precise, sensitive, and economical method has been developed, validated for the estimation of ?-? arteether in bulk pharmaceutical raw material form as per ICH guidelines Q2(R1). The method employed 5M HCl as a solvent and was used to derivatize a drug. The proposed method obeyed Beer’s law in the concentration range of 10-80?g/ml. The linear regression showed a good linear relationship with R2= 0.997, slope and intercept were 0.012 and 0.009 respectively. The method was validated statistically where SD and % RSD were found to be satisfactorily low. The average recovery of the drug for the projected method was found in the range of 99.96% indicating no interference of the excipients. The results of the pure drug analysis were validated concerning the accuracy, precision, and recovery studies which were found to be satisfactory. LOD and LOQ for ?-? arteether were found to be 0.0138?g/ml and 0.0433?g/ml respectively. The utility of the created strategy has been exhibited by examination of the business definsition containing this medication. The UV spectroscopy method showed good accuracy and precision which shows no significant difference between these methods. In this way, the proposed techniques were found to have equivalent appropriateness for assessment and routine investigation of arteether in drug crude material. Key-words:?-? Arteether, UV spectroscopy, intercept, linearity, calibration curve
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6217.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6217