ABSTRACT

Background: Acid-suppressive drugs usage is widespread in patients with osteoporosis. An association between gastric acid suppressants and increased fractures risk has been found, denoting the possible effects of chronic use of these acid suppressants, as omeprazole, pantoprazole (PPIs) and famotidine (H2 receptor antagonist). Purpose of the study: it aimed to investigate the potential impact of proton pump inhibitors and histamine-2 blocker on the bones of adult and aged female rats. Methods: Forty-eight (48) female Sprague–Dawley rats were used; they were divided into two main groups. Group A (7-week old) and group B (7-month old). Each main group was subdivided into four subgroups. Control group and omeprazole, pantoprazole, famotidine treated-groups and received drugs daily (successive 3 months). Then, blood was collected for serum calcium, alkaline phosphatase, estradiol, and osteocalcin, and femurs were processed for histopathology. Results and conclusion: Omeprazole or pantoprazole administration produced bone loss (low serum calcium, elevated serum alkaline phosphatase, and osteocalcin and decrease in cortical and trabecular bone thickness). These drugs have no effect on serum estradiol level. Their effects on bone tissue were more prominent in old rats. On the other hand, famotidine produced bone changes only in older rats. Keywords: H2 receptor antagonists; proton pump inhibitors; bones; aged; rats
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6214.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6214