ABSTRACT

Objective: The main aim of this study was to develop a spectrophotometric method for the determination of Darunavir Ethanloate in bulk. Method: Standard and working solutions of darunavir ethanolate were prepared then aliquots of working solutions of different concentrations were prepared then linearity, precision, accuracy, robustness, ruggedness, quantitation limit and detection limit were determined. Result: The linearity for this method was found to be within the range of 2-24?g/ml. Correlation coefficient (R2 ) was found to be 0.998. Regression equation was found to be y = 0.034x + 0.063. Conclusion: A simple, specific and sensitive UV spectroscopy method was developed for the evaluation of darunavir ethanolate in bulk. The projected method may be duly applied for the analysis of darunavir ethanolate in bulk for routine analysis. Keywords: Darunavir Ethanolate; UV Spectrometry; Validation; Assay
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6209.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6209