ABSTRACT

A single Centre prospective observational study. Patients (<18 years old) receiving one or more AEDs for epilepsy, at each clinically determined follow-up visit. Primary outcome was adverse reactions of AEDs. Behavioral and cognitive functions were secondary outcomes. A total of 64 patients were recruited into this study. The median age of the patients was 26.2 years. A total of 47 patients were on polytherapy and 17 on polytherapy. Over half of the patients received either Levetiracetam or carbamazepine as monotherapy. Seventy-four per cent of all AED prescriptions were old generation drugs. The most frequently prescribed drugs were Levetiracetam (42%), (9%). Conclusion: In conclusion, polytherapy increases the possibility of ADRs in patients. Physicians should give AED polytherapy only when the maximum therapeutic doses of monotherapy are ineffective. Both clinicians and parents should monitor AED treated patients for adverse reactions, especially behavioral problems and somnolence. To assess the types of ADRs in prescribed drugs, Prevention and control the adverse effects of antiepileptic drugs, Risk and benefit related to antiepileptic drugs, improving health outcomes for epilepsy patients. Keywords: Polytherapy, monotherapy, seizures, AED, ADR, Levetiracetam, carbamazepine, carbamazepine, lamotrigine, Sodium valproate
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6208.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6208