ABSTRACT

Type I pyrethroid, Permethrin is the most broadly used insecticide worldwide because of its high insecticidal potency and low mammalian toxicity. It is one of the most frequently used pyrethroid to control home pest, disease vector and protect food stuff. Although being considered safe pesticide, literature study reveals toxic implications of pyrethroid on nontarget organism on various vital tissues. Therefore, it is necessary to evaluate toxic manifestation of permethrin in liver and kidney. Hence, the objective of the current investigation was to study the effect of permethrin on hepatic and renal tissues of Swiss albino mice. Animals were divided into 3 groups namely, control, vehicle control and permethrin treated. Permethrin (130mg/kg) was administered orally via feeding canula for 21 days. Gravimetric parameters revealed reduced body weight and organ weight after administration of toxicant. Biochemical parameters assayed in liver and kidney showed reduced Protein level, cholesterol content, ATPase, SDH and ALPase enzyme activity. ACPase activity was observed to increase after permethrin administration. Altered biochemical assays may lead to oxidative stress and obstruct the normal physiological function. Keywords: Permethrin, Pyrethroid, Biochemical, Hepatotoxicity
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6202.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6202