ABSTRACT

Algesia and pyrexia are central to numerous pathological conditions. Synthetic drugs used for the treatment of these conditions cause various undesired effects. Several studies are in progress worldwide to discover therapeutic agents from natural sources with improved safety profile. The present study is aimed at evaluating in-vivo analgesic and antipyretic potential of methanol and ethanol extracts of leaves of Melia. azedarach Linn.and Psidium. guajava Linn. Analgesic activity was assessed by a tail immersion and acetic acid-induced writhing methods while Brewer’s yeast induced pyrexia method was employed to ascertain antipyretic profile. In analgesic method methanolic extract of P. guajava L. showed higher pain threshold (11.86± 0.21 sec) and maximum pain inhibition at a dose of 400 mg/kg at 120 min after administration which is almost equivalent to that of standard (12.14± 0.21 sec).While, in the second analgesic model, methanolic extracts of P. guajava L. (400mg/kg) showed maximum protection of 60.51% with least no. of writhes (7.4±1.28) and M. azedarach L. 400mg/kg ethanolic extract showed 42.90% protection with 10.7±1.16 score. In pyrexia method, P. guajava L. methanolic and ethanolic 400mg/kg dose groups showed significant changes in pyrexia i.e., 37.99± 0.26 and 38.43±0.12 while M. azedarach L. extracts showed (38.19± 0.16, 38.53±0.16) in a dose-dependent manner with increase till 2hrs later followed by steep decrease. Overall, it is concluded that P. guajava L. extracts especially methanolic groups showed marked analgesic and antipyretic activities in three models studied, this strengthens the ethnopharmacological uses of both plants as analgesic and antipyretic plant. Keywords: Analgesic, Antipyretic, Melia. azedarach L., Psidium. guajava L., Acetic acid-induced writhing, Tail immersion method and Brewer’s yeast induced pyrexia
Publication date: 01/07/2022

https://ijbpas.com/pdf/2022/July/MS_IJBPAS_2022_6198.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.7.6198