ABSTRACT

Diabetes mellitus (DM) is a heterogeneous disease, characterized by chronic hyperglycemia caused by defects in insulin secretion, insulin action, or both, resulting in problems in the metabolism and functions of carbohydrate, lipid, and protein. The objective of the present work was to investigate the Anti-hyperglycemic, antihyperlipedemic and reno-protective effects of Ginger (Zingiber officinale), Cinnamomum verum and Nigella Sativa in Streptozotocin-diabetic rats. The study was conducted from September 2016 to April 2017.In this study, rats were divided into 8 groups according to treatment regimen. Each group comprised of 5 rats. After animal sacrifice histopathological examination of kidney and pancreas was done. Histopathological examinations of kidney and pancreas showed a moderate protection of renal glomeruli and tubules, and mildprotection of pancreatic cells depending on the treatment either before or after induction of diabetes. Cinnamomum verum was found to be the best in treatment and protection of nephropathy. Keywords: Diabetes Mellitus, Zingiber Officinale, Cinnamomum Verum, Nigella Sativa, Nephroprotection
Publication date: 01/06/2017

https://ijbpas.com/pdf/2017/June/MS_IJBPAS_2017_4191.pdf

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