ABSTRACT

Thyroid functional status had been investigated in type 2 diabetic middle age and elderly subjects already receiving the treatments of insulin alone, oral antidiabetic alone and in combination of the both along the same age groups of clinically normal subjects however all not receiving any thyroid related treatment. The functional status of the gland was assessed through assaying of thyroid stimulating hormone, thyroxin, fee fraction of thyroxin, tri iodothyronine, free fraction of tri iodothyronine and reverse tri iodothyronine. In all the diabetic groups on various treatments random non fasting glycemia was well beyond 200 mg/dL. Thyroid stimulating hormones was highly significantly elevated in alone and in combination of insulin of oral antidiabetic treatments compare to the insulin alone treatment and the normal subjects’ groups. All the assayed thyroid hormones were highly significantly lowered in diabetic subjects receiving oral antidiabetic alone or in combination with insulin compare to insulin only treatment and the normal subjects’ groups. There is strong evidence that oral antidiabetic treatments adversely affect early steps of thyroid hormones’ formation which persists without any modulation at the subsequent steps thus lowering all types of thyroid hormones. Keywords: Type 2 diabetes, oral antidiabetic, insulin, thyroid stimulating hormone, thyroid hormones
Publication date: 01/06/2022

https://ijbpas.com/pdf/2022/June/MS_IJBPAS_2022_6184.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.6.6184