ABSTRACT

To investigate the cardioprotective effects of Actnidia deliciosa fruit juice [ADFFJ] against isoproterenolinduced myocardial infarction in rat myocardium. Wistar rats were pretreated with ADFFJ Cardioprotector, Isoproterenol, Myocardial Infarction, the imbalance between myocardial oxygen supply and demand. The increase produces toxic reactive oxygen species (ROS) such as O2, H2O2, OH, etc. [1, 2]. Actnidia deliciosa fruit juice (100, 200 and 400 mg/kg) orally for 21 days followed by intoxication with isoproterenol [85 mg/kg/I.P] for 2 consecutive days. Biochemical markers of myocardial infarction such as CKMB, SGOT and SGPT have been identified. In addition, the antioxidant status of cardiac tissue was evaluated by examining the activity of antioxidant enzymes such as lipid peroxidation, superoxide dismutase, reduced glutathione and catalase. The results indicated that the pretreatment of Actnidia deliciosa fruit juice significantly inhibited the decrease in antioxidants and the slow increase in markers of heart damage in isoproterenol-treated rats. Furthermore, these findings were clearly supported by the remarkable protection revealed by histopathological studies. Actnidia deliciosa fruit juice has been found to help protect the heart. Key words: Actnidia deliciosa fruit juice, Myocardial infarction, Isoproterenol, Antioxidants
Publication date: 01/06/2022

https://ijbpas.com/pdf/2022/June/MS_IJBPAS_2022_6179.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.6.6179