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ANTICONVULSANT EFFECT OF ETHANOLIC EXTRACT OF Senna singueana (DEL). LOCK ON PENTYLENE TETRAZOLE (PTZ) INDUCED CONVULSIONS IN MICE
Authors: Chakali Ayyanna , JHANSI BAI M, SHAIK ASRA FATHIMA, BHAVANA S, NAGA SHIVANI V AND MONICA P

ABSTRACT
The study was undertaken evaluate the anticonvulsant activity of Senna singueana in pentylenetetrazole (PTZ) induced seizure model in mice. In this model, 5 groups of albino mice (n=6) were used. The 1st group was kept as control, 2nd as standard (diazepam, 4 mg/kg); 3 rd - 5th were treated with Senna singueana ethanol root extract (100, 200 and 400 mg/kg). After 30 min of administration, the mice were I.P injection of PTZ (75 mg/kg). Anticonvulsant activity was confirmed by measuring the latency to PTZ -induced threshold seizures, and the duration of seizures in the mice. Extract at 400 mg/kg prolonged latency to seizure onset in PTZ model respectively. Senna singueana possess anticonvulsant effect by delay the latency of seizures produced by PTZ. Keywords: Senna singueana, Anticonvulsant, Diazepam, Pentylenetetrazole,
Publication date: 01/06/2022
    https://ijbpas.com/pdf/2022/June/MS_IJBPAS_2022_6178.pdf
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https://doi.org/10.31032/IJBPAS/2022/11.6.6178

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