ABSTRACT

Urolithiasis is a multistep bio-chemical process with high recurrence rate. Epidemiological studies discovered that urolithiasis is more seen in men than in women and is more widespread between the ages of 20 to 40 in both sexes. In ayurvedic system of medicine and also in herbal medicaments numerous actives/extracts are used for the management of urolithiasis. The present study was carried out with an objective to find out comparative evaluation of the kidney stone dissolving potential of some of the medicinal plants by using calcium oxalate crystals-titration method to know their actual efficacy. Two plant species were evaluated for its anti-urolithiatic activities In vitro. The inhibitory activity against calcium oxalate (CaOx) via aggregation assay and dissolution using titrimetric method were evaluated. The % dissolution of calcium oxalate stones by four formulations were estimated by redox titrations and the effects of four formulations on slope of nucleation and aggregation as well as CaOx crystal growth were evaluated spectrophotometrically. Cystone® Syrup showed the highest inhibitory activity against aggregation of CaOx crystals (25.13±1.19)and the same product had the most effective dissolution effect on CaOx crystals ((60.74 ± 1.63%)). The other promising methanolic plant extract of Echinops echinatus Roxb had also shown acceptable results with respect to inhibition (78.68±1.82 %) as well as dissolution (54.82 ± 1.48%) & fruit extract of Passiflora edulis Sims. had also shown acceptable results with respect to Cystone ( 52.98 ±1.39) dissolution effect and on CaOx crystals of calcium oxalate crystals in in-vitro studies. Present study has given a fare idea about the efficacy of Echinops echinatus Roxb. & Passiflora edulis Sims. extract which will be used in the management of kidney stones. Key words: In vitro, Antiurolithiatic, Dissolution, Inhibition, Comparative evaluation, Kidney stones, Echinops echinatus Roxb., Passiflora edulis Sims
Publication date: 01/06/2022

https://ijbpas.com/pdf/2022/June/MS_IJBPAS_2022_6171.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.6.6171