Isoxazole is an azole that contains nitrogen and has an oxygen atom next to it. Isoxazole rings
can be found in a range of natural substances like ibotenic acid, as well as pharmaceuticals
like valdecoxib, a COX-2 inhibitor. Many lactamase-resistant antibiotics, such as cloxacillin,
dicloxacillin, and flucloxacillin, contain furoxan, a nitric oxide donor that contains the
isoxazolyl group. The artificial danazol, an androgenic steroid, also has an isoxazole ring.
The biological actions of substituted isoxazoles have been widely documented in the
literature. Disubstituted and trisubstituted isoxazoles have been found to have a wide range of
biological actions, including antibacterial, analgesic, anti-inflammatory, antioxidant, and
anticancer properties ,agonistic activity, inhibitory activity, antihypertensive activity, and
glutamate transporter activity, as well as CNS (central nervous system) activity, antitubercular activity, and other activities such as GABA (-amino butyric acid) agonistic
activity, inhibitory activity, antihypertensive activity, and glutamate transporter activity. The
current review compiles the most recent data on the biological activity of isoxazole analogs.
Green synthesis is an environmentally friendly method for synthesizing variety of medicinal
substances.
Keywords: Isoxazole [1], Antimicrobial activity, Green synthesis, chalcones,
heterocyclic
Publication date: 01/06/2022
https://ijbpas.com/pdf/2022/June/MS_IJBPAS_2022_6141.pdf
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https://doi.org/10.31032/IJBPAS/2022/11.6.6141
