ABSTRACT

Leptin is a metabolic hormone secreted by adipose tissue. This hormone acts in the central nervous system and produces a negative feedback signal for regulation of appetite, metabolism and sexual maturation. The major hormone behind the management of weight is not given attention widely. There are adipocytokines which are secreted by the adipose cells. This adipocytokines namely, leptin, which is an adiponectin and one more adipocytokine- the tumor necrosis factor (TNF)-?, in recent days have gained a lot of attention in the medical field, and are known to be involved in weight change through roles in food intake, energy consumption, and glycolipid metabolism. Our main intention in writing this review is to highlight the role of leptin the metabolic cycle. In our detailed review, we have focused on the role of leptin, the mode of action of leptin, factors that regulate leptin, leptin resistance in obesity. Keywords: Metabolism, Obesity, Role of leptin, Leptin Resistance, Pharmacological Therapy
Publication date: 01/06/2022

https://ijbpas.com/pdf/2022/June/MS_IJBPAS_2022_6140.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.6.6140