ABSTRACT

The purpose of this research was to formulate, characterize, the Valsartan Nasal Microparticles encapsulated in dried Lipidium sativum mucilage based spray dried mucoadhesive microspheres for treating hypertension. Factorial design has been employed for the assessment of influence of three independent variables, inlet temperature, feed flow rate and drug–polymer ratio on production yield, particle size, and in vitro drug diffusion. Microparticles were evaluated for particle size, entrapment efficiency, swelling property, in vitro mucoadhesion, in vitro drug diffusion and stability studies. The result of differential scanning thermogram of Valsartan microparticles showed the peak at 109.76 °C and polymer at 263.47 °C. This DSC study further confirmed that there was no drug-polymer interaction in microparticles. X-ray diffraction The diffractogram of isolated polymer showed the characteristic sharp peak at 9.2°, 12.5°, 17° and 27.6° due to presence of particles in geometrical shape and it indicated the polymer is crystalline in nature. From the SEM photographs, it was observed that microparticles were found to be 5 µm in size and spherical in shape having smooth surface morphology. FT-IR analysis of optimized formulation showed that the polymer and process parameters do not alter the performance characteristic of drug, thus revealing stability of the finalized formulation. The best fit model for the drug release was found to be Zero Order Model as indicated by higher R2 value. This proved that the formulated microparticles showed sustained release. The mechanism for drug release was followed Korsmeyer-peppas model as indicated by higher R2 value. It predicts that the drug release is polymer concentration dependent which follows zero order model and polymer having swelling and eroding properties which follows Korsmeyer-peppas model. Keywords: Valsartan Nasal Microparticles, differential scanning thermogram, SEM, FT-IR analysis
Publication date: 01/06/2022

https://ijbpas.com/pdf/2022/June/MS_IJBPAS_2022_6132.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.6.6132