ABSTRACT

Vigna mungo and Vigna radiata belongs to the very important group of plant food stuffs and is known as legumes. They are rich source of bioactive compounds apart from their nutritional compounds. In the present study seeds of both the plants were selected for the study. Seeds were subjected to the extraction by using ethanol water as a solvent system. Extracts obtained are then fractionated by using column chromatography. Total four fractions were collected. These fractions were subjected to the preliminary phytochemical analysis. Isolated fractions were evaluated for anticancer activity by using modified Murine tumor model. From column chromatography total four fractions were isolated, two from Vigna mungo (VMF1 &VMF2) and two from Vigna radiata (VRF3 & VRF4). VMF1 and VMF2 was indicating presence of the flavonoids and phenolic compounds in significant concentrations. VRF3 and VRF4 of Vigna radiata were indicating the flavonoid and phenolic compounds. In the Murine tumor model, all the results showing that VMF1, VMF2, VRF3 and VRF4 produced mild to moderate effect on tumor inhibition. Vigna mungo and Vigna radiata fractions were showing anticancer activity. This activity may be due to presence of antioxidant compounds which acts as radical scavengers Key words: Vigna mungo, Vigna radiata, Murine tumor model, anticancer activity
Publication date: 01/05/2022

https://ijbpas.com/pdf/2022/May/MS_IJBPAS_2022_6118.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.5.6118