ABSTRACT

Acute kidney injury (AKI) is characterized by rapid loss of kidney function, associated with renal cell death. Epidemiology of AKI differs in developed countries from that in developing countries. In developed countries, the AKI predominates in the elderly people whereas in developing countries AKI is prevalent among young people and children. The various reasons for post-renal AKI include renal papillary necrosis, kidney stones, bladder tumor, carcinoma of cervix and prostrate hypertrophy. Ischemia reperfusion injury is the most common cause of Acute kidney injury. Ischemia causes impairment of renal functions by inducing renal vasoconstriction, renal tubular obstruction, tubular leakage of glomerular filterate and decreased glomerular permeability. GABA is the major inhibitory neurotransmitter in the brain and its role is extensively studied in various disorders including anxiety and epilepsy. The renoprotective effects of GABA has also been reported in animal model of glycerol-induced acute kidney injury. GABA released from renal tubular epithelium and transported with the urine might be involved in the modulation of contractility in the urinary tract. Keywords: Acute kidney injury, Ischemia reperfusion, Oxidative stress, gamma amino butyric acid, angiotensin, Nitrous oxide
Publication date: 01/05/2022

https://ijbpas.com/pdf/2022/May/MS_IJBPAS_2022_6094.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.5.6094