ABSTRACT

The human gut microbiota becomes a hotspot of research attention owing to its close association with human health and human diseases. The modern diet is a meal that contains high levels of refined sugar, refined grain, trans fat, and polyunsaturated fat, salt, and numerous food additives. In this pretext, the global nutrition transition from a traditional diet primarily rich in complex carbohydrates and fibre to a modern diet has provoked an alarming situation. Mouse models have been extensively used to elucidate the complex hostmicrobiome interplay in nutrition and diseases development. The interpretation of gut microbiome research in mouse models in the context of human milieus requires the knowledge of intrinsic similarity and difference between two systems. The large body of evidence proves that mice microbiota are similar in the context of human microbiota except for some difference that might reflect the disparities in host factors including genetic origin, diet, gender and sex. Moreover, some dissimilarity even reported by different researchers are due to limited dataset size and diversity of studies. Moreover, few published articles have also represented the change in gut microbial composition as a combination of order, family, genus and species, which confuses during the analysis of outcomes. In this review article, we compiled the comparison of gut microbiota alteration induced by high fat and high salt dietary interventions in both hosts up to lower taxonomic levels based on published reports. Keywords: Gut Microbiota, Classification, Murine models, High fat diet, and High salt diet
Publication date: 01/05/2022

https://ijbpas.com/pdf/2022/May/MS_IJBPAS_2022_6081.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.5.6081