ABSTRACT

The present work was designed to trace out probable antidiabetic activities of different phytoconstituents of Limonia acidissima. The study was additionally expected to correlate connection between different phytoconstituents with significant 6 receptors assuming significant part in diabetes mellitus by in silico procedures. ADMET filters applied to all of the phytoconstituents using ADMETLab. Shortlisted phytoconstituents were further explore through molecular docking. Main six PDB’s 1IR3, 1US0, 2FV6, 2OQV, 5NN6 and 2QV4 for Insulin receptor, Aldose Reductase, Protein tyrosine phosphatase 1, Human Dipeptidyl Peptidase IV (DPP4), Alpha amylase and Alpha Reductase respectively appraise in the study. Total 22 molecules screened through ADMETLab. Out of which twelve shows good ADMET profile. Molegro Virtual Docker 6.0 utilized for entire investigation. Out of twelve selected phytoconstituents six shows best docking results in contrast to internal ligands and standard drug Glibenclamide. These compounds include Aurapten, Burgapten, Hederatriol, Marmin Syringaresinol and Yangambin. The entire estimation gives idea that plant likely has antidiabetic potential due to presence of quality of biomolecules. Keywords: Molegro Virtual Docker, Antidiabetic, Syringaresinol, Diabetes Mellitus, ADMET
Publication date: 01/05/2022

https://ijbpas.com/pdf/2022/May/MS_IJBPAS_2022_6072.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.5.6072