ABSTRACT

Aim: To evaluate the antimicrobial efficacy of fucoidan derivatives against oral pathogens. Methodology: After characterization of the prepared solutions of ampicillin loaded fucoidan nanoparticles and fucoidan coated metal nanoparticles, the antimicrobial activity of the solutions were assessed againt Candida albicans, Staphylococcus aureus, Streptococcus mutans and Enterococcus faecalis by zone inhibition method (agar well diffusion method) and MTT method. MIC of bacterial strains for fucoidan coated metal nanoparticles and fucoidan loaded ampicillin drug was determined according to the broth micro-dilution method. Results: A statistically significant antimicrobial activity was seen at the MIC of 200µL of Fucoidan-chitosan-ampicillin nanoparticles against all the microbial strains tested. Fucoidanchitosan silver nanoparticles showed antimicrobial activity at the MIC of 100µL against Candida albicans, Staphylococcus aureus and Streptococcus mutans and a MIC of 200µ against Enterococcus faecalis. Conclusion: The study concluded that fucoidan derivatives such as fucoidan-chitosanampicillin nanoparticles and fucoidan-chitosan silver nanoparticles can be used as effective antimicrobial agents againt oral pathogens. Keywords: Fucoidan, antimicrobial, oral, pathogens
Publication date: 01/05/2022

https://ijbpas.com/pdf/2022/May/MS_IJBPAS_2022_6061.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.5.6061