ABSTRACT

Synthesized compounds were screened for antimicrobial activity by poar plate method. The potency of this present work deals with synthesis, characterization and biological activity of some new Azetidinones derivatives derived from cyclohexanones. Different Schiff bases derivatives were obtained from different substituted or unsubstituted anilines upon treatment acetamide with toluene. A Schiff base on reaction with chloroacetyl chloride gives the different azetidinones. The final derivatives of Azetidinones were obtained by reaction with chloro acetyl chloride which gives different types of Azetidinones derivatives. The structure of the newly synthesized compounds has been established on the basis of their spectral data and elemental analysis. The docking study has done of all compounds by using 3U2D S. aureus GyrB ATPase domain in complex with the small molecule inhibitor. The synthesized compounds were determined against standard drug Amoxicillin by measuring the zone of inhibition and calculating the MIC. Keyword: Azetidinones, Schiff Base, Antimicrobial activity

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https://doi.org/10.31032/IJBPAS/2022/11.5.5961