ABSTRACT

This research was conducted to evaluate creams formulated using ethanolic extract of Carica papaya leaves. The leaves were collected; dried, and extracted by maceration method using ethanol. The antimicrobial activity of extract was determined using the pour plate method for viable counts and the minimum inhibitory concentration (MIC) by agar diffusion method. Test organisms used were Staphylococcus aureus, Bacilus subtilis, Pseudomonas aeruginosa, Escherichia coli, Aspergillus niger and Candida albicans. Carica papaya leaves ethanolic extract creams were formulated and evaluated for antimicrobial activity and physicochemical properties. The extract had good antimicrobial activity and MIC of 3.125 mg/ml against all the test organisms except Aspergillus niger which was not sensitive even at 100 mg/ml extract concentration. All the formulated creams retained their antibacterial activity but only Formulations F5 to F7 retained their antifungal activity against Candida albicans. The pH of the creams ranged from 4.6 to 7.6, while the viscosity was from 9790 to 95,100 mPas. All the creams were ranked excellent in terms of homogeneity and ease of removal. The spreadability ranged from 2.8±0.00 to 5.35±0.21 cm. This study showed that creams formulated using ethanolic extract Carica papaya leaves have good antimicrobial and physicochemical properties. Keywords: Carica papaya, cream, antimicrobials, bacteria, ethanolic extract
Publication date: 01/05/2022

https://ijbpas.com/pdf/2022/May/MS_IJBPAS_2022_5942.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.5.5942