ABSTRACT

Purpose: The ultimate aim of this current study was to design of sustained release matrix tablets for valdecoxib. Methodology: SR matrix tablets of were formulated by using wet granulation technique with different polymers. The formulated SR matrix tablets are evaluated by characterization of flow properties like angle of repose, bulk density, compressibility index, hausner’s ratio and characterization of physiochemical properties such as thickness, diameter, weight variation test, hardness, friability, drug content, in vitro drug release studies. Drug-polymers interaction was predicted by FT/IR Spectroscopy and DSC method. Results: The SR matrix tablets were formulated and evaluated for flow properties, physiochemical characterization of matrix tablets, in vitro drug release studies. The in vitro dissolution studies revealed that the release patterns of the VC8 containing HPMC K100M and ethyl cellulose were probably showing maximum retardation of drug release and it shows super case-II transport, for these reasons, it was considered that the formulation VC8 as best formulation among all the nine formulations. Conclusion: The results encourage a potential use of SR matrix tablet to prolong the dissolution rate and hence its improvement in treatment efficacy and patient compliances through oral route. Keywords: HPMC K100M, ethyl cellulose, microcrystalline cellulose, PVP K30, valdecoxib
Publication date: 01/05/2022

https://ijbpas.com/pdf/2022/May/MS_IJBPAS_2022_5346.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.5.5346