Curcumin is a hydrophobic polyphenol obtained from Turmeric. Two major components, namely
desmethoxycurcumin (DMC, 2) (20 to 30 percent) and bisdemethoxycurcumin (BDMC, 3), are
associated with curcumin, the major curcuminoid (50 to 60 percent).The main explanation for
this is that curcumin has a low oral bioavailability in humans, which means it is scarcely
absorbed. Curcumin oral bioavailability is low due to its limited water solubility, bio
accessibility, fast digestion, tissue distribution, Poor liquid, and gastro-intestinal fluid solubility
and excretion. Approaches to increasing the bioavailability and preparation of more bioavailable
formulation such as Consuming curcumin with fatty materials, Addition of matrices, etc. are
studied. Various types of nanocarriers have been developed to enhance oral curcumin
bioavailability, including nanoparticles, phospholipid complexation, nanoemulsion, solid
dispersion, liposome, piperine as penetration enhancer, and other adjuvants. Micro-carriers are
larger than Nano-carriers. Reducing the size of the carrier enables it to carry the drug molecule
across the cell membrane barriers. Pharmacokinetic data studies the AUC and Cmax of different
formulations of curcumin, resulting in increased bioavailability of curcumin loaded with
nanoparticles in comparison with unencapsulated curcumin powder.
Keywords: Curcumin, desmethoxycurcumin, bisdemethoxycurcumin, curcuminoid, bio
accessibility, nanocarriers, etc.
Publication date: 01/04/2022
https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_6039.pdf
Download PDF
https://doi.org/10.31032/IJBPAS/2022/11.4.6039
