ABSTRACT

The objective of the study was to increase the solubility and dissolution rate of valsartan (VAL), a poorly water-soluble drug which is an angiotensin II blocker which forms an inclusion complexation with ?-cyclodextrin (?-CD), hydroxypropyl-?-cyclodextrin (HP-?-CD). The phase solubility studies indicated that the solubility of valsartan was significantly increased in the presence of ?-CD and also in the presence of HP-?-CD and AL type curve was obtained. Apparent stability constant (Ks) was found to be 165.4±M-1 for ?-CD and 296±3 M-1for HP-?CD. The inclusion complexes were by kneading method, solvent evaporation method and spray drying method. The prepared complexes were characterized using FTIR, DSC. The inclusion complexes dissolution profile was compared with physical mixture and pure drug. All the complexes showed improved dissolution rate. The inclusion complexes compared with HP-?-CD by spray drying method exhibit greatest enhancement in solubility and dissolution rate i.e., 94.3% VAL release in 60min. Keywords: 2-Hydroxypropyl-?-cyclodextrin, ?-cyclodextrin, kneading method, solvent evaporation method, spray drying method
Publication date: 01/04/2022

https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_6038.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.4.6038