ABSTRACT

PTZ-induced kindling causes memory disruption in rats is a consequence of changes within the central nervous system that are secondary to impaired oxidative stress. Treatment with antioxidants are reported to produce beneficial effects in animal models. Ellagic acid reported to exhibit antioxidant effect. However, no report is available on the influence of ellagic acid on PTZ-induced kindling causes memory impairment. Therefore, we tested its influence against cognitive dysfunction in PTZ-induced epileptic rats using passive avoidance test. Lipid peroxidation and glutathione levels as parameter of oxidative stress were assessed in the hippocampus. After induction of epilepsy PTZ treated rats showed a severe deficit in learning and memory associated with increased lipid peroxidation, decreased glutathione activity. In contrast, treatment with ellagic acid (7.5-30 mg/kg, p.o.) improved cognitive performance, and lowered oxidative stress in PTZ treated rats. In conclusion, the present study demonstrates that treatment with ellagic acid prevents the changes in oxidative stress and consequently memory impairment in PTZ treated rats. Keywords: Ellagic acid; PTZ-induced kindling; Memory impairment; Oxidative stress, Passive avoidance test
Publication date: 01/04/2022

https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_6017.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.4.6017