ABSTRACT

Objective: A simple, precise, accurate and cost effective UV-visible spectrometry method and validation for water soluble Metoprolol succinate in the modified release pellet formulation and MUPS tablets. Method: Analytical method development and validation was done as per ICH Q2 (R1) guideline Results: The absorption maxima of Metoprolol succinate was found to be 274nm for all three solvents. The method represents correlation coefficient (R2 =0.999) at concentration range of 50 to 160 ?g/ml. The validation of method was done and the percent relative standard deviation of inter-day and intra-day precision range for 0.1N HCl was (0.24-1.83) & (0.0.91-1.84);for pH 4.5 Acetate buffer was (0.12-1.99) & (0.17-1.89) and for pH 6.8 phosphate buffer was (1.00-1.95) & (0.49-1.92) respectively, which shows the method was precise. The recovery of Metoprolol succinate was found to be 97.08 - 99.03 %. Conclusion: This validated precise UV- visible spectrometry method can be applied for the estimation of Metoprolol succinate with respect to the determination of assay content for the solid dosage form. Keywords: Metoprolol succinate, Modified release pellets, Validation, MUPS
Publication date: 01/04/2022

https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_6003.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.4.6003