ABSTRACT

The purpose of present research work to synthesize hydrazide based Benzoxazole derivatives, the hydrazide group was achieved by treatment of corresponding Ester with hydrazine hydrate in methanol at room temperature. Benzoxazole have extraordinary potential in biological activity. Benzoxazole is prepared by microwave assisted reaction and hydrazide compound react with substituted benzoic acid and other reactants to give desired products. The substituted benzoic acid compounds get cyclized to give (1,3)-cyclazolo- (4,5-pthalazine5)6H)-one compounds. The synthesized compounds were characterized by spectroscopy techniques like IR, MASS and evaluate their physical constant and purity by TLC. The target compounds were in-vitro evaluated against M. tuberculosis using H37Rv strain. The activity screened by MABA using pyrazinamide as standard and DMSO as control. The majority of compounds shows their potential with MIC range 3.25ug/ml. All compounds shows prominant activity except two compounds. Keywords: Anti-tubercular, Benzoxazole, MABA, Hydrazide, H37Rv
Publication date: 01/04/2022

https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_6000.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.4.6000