A REVIEW ON POLYMERIC NANOPARTICLES (PN) WITH SPECIAL EMPHASIS ON LYCOPENE AS PROTOTYPE Authors: Gurav P
ABSTRACT
Drug absorption from the GI tract can be limited by a variety of factors most significant
contributor being poor aqueous solubility and poor permeability of the drug molecule. When
administered an active agent orally it must first dissolve in gastric and / or intestinal fluids before
it can permeate the membrane of the GIT to reach systemic circulation. Hence, two areas of
pharmaceutical research that focus on improving the oral bioavailability of active agent include ;
enhancing of solubility and dissolution rate of poorly water soluble drugs. Lycopene has
attracted considerable attention as a natural chemo preventive agent through various properties
including its potent antioxidant properties. Hence, this review primarily focuses on solubility
enhancement of lycopene and methods for development of polymeric nanoparticles.
Keywords: Nanoparticles; Lycopene; Solubility Enhancement Publication date: 01/04/2022 https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_5999.pdfDownload PDFhttps://doi.org/10.31032/IJBPAS/2022/11.4.5999
