ABSTRACT

Natural products obtained from marine sources are endowed with promising pharmacological activities, thus representing invaluable leads in the drug discovery. The aim of this review is to highlight the work on natural marine product Bryostatin 1 with around 20 naturally available derivatives. This review compiles the comprehensive updated information of Bryostatin 1 including its biological source, geographical distribution, structure, characterization, synthesis and its role as isozyme Protein kinase C inhibitor. Also detail of role of Protein kinase C in Alzheimer and cancer pathology and relevance of Bryostatin 1. It is found to be enhancing memory and improving behavior in Alzheimer disease and it also enhances memory in normal person. The research for Alzheimer disease is in phase II clinical trial. This work encourage the researchers for further work on the marine product. The comprehensive information from the review will be helpful for researchers to focus on the preferential research areas yet to be examined and after structural modification of Bryostatin can be exploited as lead molecules for other pharmacological activities. Keywords: Bryostatin1; Marine product; Protein kinase C
Publication date: 01/04/2022

https://ijbpas.com/pdf/2022/April/MS_IJBPAS_2022_5994.pdf

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https://doi.org/10.31032/IJBPAS/2022/11.4.5994